Vijay Kumar Pandey

癌症的分子基础（The molecular basis of cancer）

癌症研究中的新兴概念（Emerging concepts in cancer research）

主要研究方向：

（1）发现和验证人类恶性肿瘤中的新分子治疗靶点；

（2）肿瘤细胞生物学，主要包括与癌细胞干细胞相关的细胞代谢、转移、治疗耐药性和肿瘤复发相关机制的研究；

（3）转化研究：开发针对致癌标记物的治疗诊断技术。

海外科研合作基金科研合作项目

深圳市重点实验室和启动项目

高校稳定资助重点项目

国家自然科学基金委员会面上项目

[1] Pandey, V., Wu, Z. S., Zhang, M., Li, R., Zhang, J., Zhu, T. and Lobie, P. E., Trefoil factor 3 promotes metastatic seeding and predicts poor survival outcome of patients with mammary carcinoma. Breast Cancer Res, 2014. 16(5): p. 429.

[2] Pandey V, Zhang M, Chong QY, You M, Raquib AR, Pandey AK, Liu DX, Liu L, Ma L, Jha S, Wu ZS, Zhu T, Lobie PE. Hypomethylation associated enhanced transcription of trefoil factor-3 mediates tamoxifen-stimulated oncogenicity of ER+ endometrial carcinoma cells. Oncotarget. 2017 Aug 24;8(44):77268-77291. doi: 10.18632/oncotarget.20461. PMID: 29100386; PMCID: PMC5652779.

[3] Pandey, V., Wang, B., Mohan, C. D., Raquib, A. R., Rangappa, S., Srinivasa, V., Fuchs, J. E., Girish, K. S., Zhu, T., Bender, A., Ma, L., Yin, Z., Basappa, Rangappa, K. S. and Lobie, P. E., Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation. Proc Natl Acad Sci U S A, 2018. 115(44): p. E10505-e10514.

[4] Pandey, V., Zhang, M., You, M., Zhang, W., Chen, R., Zhang, W., Ma, L., Wu, Z. S., Zhu, T., Xu, X. Q., and Lobie, P. E., Expression of two non-mutated genetic elements is sufficient to stimulate oncogenic transformation of human mammary epithelial cells. Cell Death Dis, 2018. 9(12): p. 1147.

[5] Tan, Y. Q., Zhang, X., Zhang, S., Zhu, T., Garg, M., Lobie, P. E. and Pandey, V., Mitochondria: The metabolic switch of cellular oncogenic transformation. Biochim Biophys Acta Rev Cancer, 2021. 1876(1): p. 188534.

[6] Cheng F, Wang X, Chiou YS, He C, Guo H, Tan YQ, Basappa B, Zhu T, Pandey V, Lobie PE. Trefoil factor 3 promotes pancreatic carcinoma progression via WNT pathway activation mediated by enhanced WNT ligand expression. Cell Death Dis. 2022 Mar 25;13(3):265. doi: 10.1038/s41419-022-04700-4. PMID: 35332126; PMCID: PMC8948291.

[7] Bhardwaj V, Tan YQ, Wu MM, Ma L, Zhu T, Lobie PE, Pandey V. Long non-coding RNAs in recurrent ovarian cancer: Theranostic perspectives. Cancer Lett. 2021 Apr 1;502:97-107. doi: 10.1016/j.canlet.2020.12.042. Epub 2021 Jan 8. PMID: 33429007.

[8] Zhuang QS, Sun XB, Chong QY, Banerjee A, Zhang M, Wu ZS, Zhu T, Pandey V, Lobie PE. ARTEMIN Promotes Oncogenicity and Resistance to 5-Fluorouracil in Colorectal Carcinoma by p44/42 MAPK Dependent Expression of CDH2. Front Oncol. 2021 Aug 6;11:712348. doi: 10.3389/fonc.2021.712348. PMID: 34422665; PMCID: PMC8377398.

1. Title: Compounds as modulator of JAK-STAT pathway, methods, and applications thereof (co-inventor)US Patent number 9604974, Application number 15/004,114 (Industry Liaison Office (ILO) NUS Ref: 15042N-US

2. Title: Adamantyl-tethered thiazolyl-pyrazolines, methods and applications thereof (co-inventor), Indian complete patent application No. 201641024910 (ILO NUS Ref: 2016-239-01)

3. Title: Compounds (co-inventor) application number PCT/SG2018/050194, NUS, ILO Ref: 15044N-UK/PRV.

4. Title: Compounds As Inhibitors of Tff3 Dimerization, Methods and Applications Thereof (co-inventor)Singapore provisional application number 10201704579V. ILO, NUS Ref: 2016-238-01.

2009                       Postdoctoral Fellowship, Dept. of Human & Molecular    Genetics, VCU, USA

2009                       Travel Award, 21st Lorne Cancer Conference, Lorne, Australia

2007, 2008, 2009   Travel Award, National Research Centre for Growth and Development (NRCGD), NZ

2006                       International Doctoral Scholarship, NRCGD, NZ